The MRC-5 cell line was developed in September 1966 from lung
tissue taken from a 14 week fetus aborted for psychiatric reason from a 27 year old
physically healthy woman. The cell morphology is fibroblast-like. The karyotype is 46,XY;
normal diploid male. Cumulative population doublings to senescence is 42-48. G6PD
isoenzyme is type B.
Used in Hepatitis A, Rabies
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Price:
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References:
Borsi L, Balza E, Gaggero B, Allemanni
G, Zardi L, J Biol Chem 270:6243-5 (1995) The alternative splicing pattern of
the tenascin-C pre-mRNA is controlled by the extracellular pH. PubMed ID: 7534307
Futreal PA, Cochran C, Marks JR,
Iglehart JD, Zimmerman W, Barrett JC, Wiseman RW, Cancer Res 54:1791-4 (1994)
Mutation analysis of the THRA1 gene in breast cancer: deletion/fusion of the gene to a
novel sequence on 17q in the BT474 cell line. PubMed ID: 7511052
Kilfeather SA, Collins D, McCormack P,
Cotter T, O'Malley K, Mech Ageing Dev 63:247-56 (1992) The effect of in vitro
aging on human lung fibroblast beta-adrenergic receptor density, coupling and response. PubMed ID: 1319530
Jacobs, Nature 277:168
(1970), Characteristics of a human diploid cell designated MRC-5.
